1岁以下单卵双胞胎同时患1型糖尿病。

Simultaneous onset of type 1 diabetes in monozygotic twins younger than 1 year.

作者信息

Uchida Noriko, Amano Yoshiro, Akazawa Yohei, Nakamura Shinichi, Minami Isaki, Washizawa Kazuhiko, Wakabayashi Yasunobu, Yasui Kozo

机构信息

Department of Pediatrics, Nagano Red Cross Hospital, Wakasato 5-22-1, Nagano, 380-8582, Japan.

出版信息

Eur J Pediatr. 2008 Feb;167(2):161-3. doi: 10.1007/s00431-007-0442-y. Epub 2007 Mar 15.

DOI:10.1007/s00431-007-0442-y

PMID:17361417

Abstract

This report describes type 1 insulin deficient diabetes mellitus (IDDM) arising in identical twins aged under one year. One twin presented with symptoms and was diagnosed with type 1 IDDM; the diagnosis of type 1 IDDM was simultaneously made in the second twin without clinical symptoms. Both twins were positive for anti-GAD (glutamic acid decarboxylase) antibody at first, and then positive for islet cell antibodies. Interestingly, the twins have four susceptible HLA DR and DQ genes together that are usually recognized separately in IDDM patients in Japan.

摘要

本报告描述了一对不满一岁的同卵双胞胎中出现的1型胰岛素缺乏型糖尿病（IDDM）。其中一个双胞胎出现症状并被诊断为1型IDDM；另一个没有临床症状的双胞胎同时被诊断为1型IDDM。起初，两个双胞胎的抗谷氨酸脱羧酶（GAD）抗体均呈阳性，随后胰岛细胞抗体也呈阳性。有趣的是，这对双胞胎共同拥有四个易感的人类白细胞抗原（HLA）DR和DQ基因，而在日本的IDDM患者中，这些基因通常是分别被识别的。