Jiang Hong, Chen Su-hua, Wen Liang-zhen
Department of Gynecology and Obstetrics, the 105th Hospital of PLA, Hefei (230031).
Chin J Integr Med. 2006 Dec;12(4):250-4. doi: 10.1007/s11655-006-0250-3.
To evaluate the effects of Jinye Baidu Granule ( JYBDG), a traditional Chinese medicine compound prescription, on fetal growth and development with maternal active human cytomegalovirus infection.
A prospective, randomized and controlled trial was adopted during January 1996 to June 2002. From the pregnant women with an abnormal pregnant history, 240 cases were screened to be infected by human cytomegalovirus (HCMV) by enzyme-linked immunoabsorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR). They were assigned according to the random number table to two groups. The 122 cases in the treatment group were administrated with JYBDG, one package each time, three times a day for two continuous weeks, while the other 118 in the control group did not receive any treatment. The negative conversion rate of both HCMV-IgM and HCMV late mRNA, the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate between the two groups were compared, and fetal growth and development in partial fetuses were also observed.
The negative conversion rate of both HCMV-lgM and HCMV late mRNA, the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate in the treatment group were 77. 05% (94/122), 48. 98% (48/98) and 21.74% (10/46) respectively, while those in the control group were 38. 14% (45/118), 67.50% (54/80) and 52.63% (20/38) respectively, all showing significant difference between the two groups (P<0. 01). Totally 35 normal infants and 11 abnormal infants were born in the treatment group, and the number in the control group was 20 and 18 respectively, and comparison between the two groups showed significant difference (P<0.01). Six months of child birth, the scores of both mental development index (MDI) and psychomotor development index (PDI) of infants were higher in the treatment group (20 cases) than those in the control group (20 cases), but there was no significant difference between the two groups (P>0.05).
JYBDG could decrease the intrauterine transmission of HCMV and is beneficial to fetal growth and development.
评价中药复方制剂金叶败毒颗粒（JYBDG）对孕妇活动性人巨细胞病毒感染时胎儿生长发育的影响。
采用前瞻性、随机对照试验，时间为1996年1月至2002年6月。从有异常孕史的孕妇中，通过酶联免疫吸附试验（ELISA）和逆转录聚合酶链反应（RT-PCR）筛选出240例人巨细胞病毒（HCMV）感染患者。根据随机数字表将其分为两组。治疗组122例给予金叶败毒颗粒，每次1包，每日3次，连续服用2周；对照组118例未接受任何治疗。比较两组HCMV-IgM和HCMV晚期mRNA的转阴率、胎盘HCMV-DNA阳性率及宫内传播率，并观察部分胎儿的生长发育情况。
治疗组HCMV-lgM和HCMV晚期mRNA的转阴率、胎盘HCMV-DNA阳性率及宫内传播率分别为77.05%（94/122）、48.98%（48/98）和21.74%（10/46），对照组分别为38.14%（45/118）、67.50%（54/80）和52.63%（20/38），两组比较差异均有统计学意义（P<0.01）。治疗组共出生正常婴儿35例，异常婴儿11例；对照组分别为20例和18例，两组比较差异有统计学意义（P<0.01）。产后6个月，治疗组（20例）婴儿的智力发育指数（MDI）和心理运动发育指数（PDI）评分均高于对照组（20例），但两组比较差异无统计学意义（P>0.05）。
金叶败毒颗粒可降低HCMV宫内传播，有利于胎儿生长发育。
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