口服避孕药：青春期女孩的副作用与抑郁
Oral contraceptives: side effects and depression in adolescent girls.
作者信息
O'Connell Katharine, Davis Anne R, Kerns Jennifer
机构信息
Department of Obstetrics and Gynecology, Columbia University, New York, NY 10032, USA.
出版信息
Contraception. 2007 Apr;75(4):299-304. doi: 10.1016/j.contraception.2006.09.008. Epub 2007 Feb 26.
OBJECTIVE
The study was undertaken to determine the side effects, including depression, of oral contraceptives (OCs) in adolescent girls.
METHODS
We conducted a randomized trial of OCs for dysmenorrhea, which assessed side effects and depression. Seventy-six adolescents received an OC (20 microg of ethinyl estradiol/100 mg of levonorgestrel) or a placebo in a double-blind fashion for 3 months. We ascertained OC side effects using open-ended and closed question formats. Participants self-administered the Center for Epidemiologic Studies Depression Scale (CES-D) to assess depressive symptoms.
RESULTS
Fifty-seven participants (77%) reported at least one side effect (median=2, range=0-8, interquartile range=1.0-3.25). The number and the type of side effects reported in the OC group and in the placebo group were similar. Mean exit CES-D scores were comparable between groups [OC group, 14.0 (SD=9.2); placebo group, 14.4 (SD=8.1); p=.86].
CONCLUSION
Adolescents treated with an OC or a placebo experienced similar numbers and types of OC side effects, as well as depressive symptoms.
目的
开展本研究以确定口服避孕药（OCs）对青春期女孩的副作用，包括抑郁。
方法
我们针对痛经进行了一项口服避孕药的随机试验，评估其副作用和抑郁情况。76名青少年以双盲方式接受了口服避孕药（20微克炔雌醇/100毫克左炔诺孕酮）或安慰剂，为期3个月。我们通过开放式和封闭式问题形式确定口服避孕药的副作用。参与者自行填写流行病学研究中心抑郁量表（CES-D）以评估抑郁症状。
结果
57名参与者（77%）报告了至少一种副作用（中位数=2，范围=0-8，四分位间距=1.0-3.25）。口服避孕药组和安慰剂组报告的副作用数量和类型相似。两组的平均退出时CES-D评分相当[口服避孕药组，14.0（标准差=9.2）；安慰剂组，14.4（标准差=8.1）；p=0.86]。
结论
接受口服避孕药或安慰剂治疗的青少年经历的口服避孕药副作用数量和类型以及抑郁症状相似。
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