灌注CT能否区分阿尔茨海默病与血管性痴呆及混合性痴呆？初步报告。

Does perfusion CT enable differentiating Alzheimer's disease from vascular dementia and mixed dementia? A preliminary report.

作者信息

Zimny Anna, Sasiadek Marek, Leszek Jerzy, Czarnecka Anna, Trypka Elzbieta, Kiejna Andrzej

机构信息

Department of Neuroradiology, Wroclaw Medical University, ul. Skłodowskiej-Curie 58, 53-569 Wroclaw, Poland.

出版信息

J Neurol Sci. 2007 Jun 15;257(1-2):114-20. doi: 10.1016/j.jns.2007.01.051. Epub 2007 Mar 23.

DOI:10.1016/j.jns.2007.01.051

PMID:17362998

Abstract

UNLABELLED

The purpose of the study was to evaluate the usefulness of perfusion CT (pCT) in differentiating Alzheimer's disease (AD) from vascular dementia (VaD) and mixed dementia (MixD). pCT was performed in 41 patients (mean age, 68.3 years): 24 with AD, 8 with VaD, and 9 with MixD. Regional perfusion parameters (rCBF, rCBV, and rMTT) were calculated from 31 ROIs in the grey and white matter of the frontal and temporal lobes, basal ganglia, and internal capsules bilaterally. The obtained data for the subgroups of AD, VaD, and MixD patients were compared statistically.

CONCLUSIONS

On the basis of rCBF and rCBV values, pCT may be a valuable method of distinguishing between AD and VaD but it seems to be of little significance in differentiating MixD from VaD and of no usefulness in distinguishing between AD and MixD.

摘要

未标注

本研究的目的是评估灌注CT（pCT）在区分阿尔茨海默病（AD）与血管性痴呆（VaD）及混合性痴呆（MixD）方面的效用。对41例患者（平均年龄68.3岁）进行了pCT检查：24例AD患者，8例VaD患者，9例MixD患者。从双侧额叶和颞叶、基底神经节及内囊的灰质和白质中的31个感兴趣区（ROI）计算区域灌注参数（rCBF、rCBV和rMTT）。对AD、VaD和MixD患者亚组获得的数据进行统计学比较。