在环境可控条件下，对患有慢性阻塞性肺病的马匹使用泼尼松龙和地塞米松效果的比较。

Comparison of prednisolone and dexamethasone effects in the presence of environmental control in heaves-affected horses.

作者信息

Couroucé-Malblanc Anne, Fortier Guillaume, Pronost Stéphane, Siliart Brigitte, Brachet Guillaume

机构信息

UPSP 5304 de Physiopathologie Animale et Pharmacologie fonctionnelle, Ecole Nationale Vétérinaire de Nantes, Atlanpôle - La Chantrerie, 44 307 Nantes Cedex, France.

出版信息

Vet J. 2008 Feb;175(2):227-33. doi: 10.1016/j.tvjl.2006.12.006. Epub 2007 Mar 23.

DOI:10.1016/j.tvjl.2006.12.006

PMID:17363304

Abstract

This study was designed to compare the efficacy of oral prednisolone and intramuscular (IM) dexamethasone in heaves-affected horses with environmental control. A total of 16 horses, aged 8-20years, with heaves were included in the study. Complete examinations were performed on Day 0 (before treatment), Day 13 (after treatment) and Day 30. Clinical variables, arterial blood gases, mucus scoring and carina evaluation (during endoscopy), and bronchoalveolar lavage (BAL) cytological analysis were all assessed. The horses were randomly assigned to receive either oral prednisolone (1mg/kg) or IM dexamethasone (0.1mg/kg). The animals were clinically scored and mucus accumulation evaluated. Results were analysed by repeated measures ANOVA with time (days of treatment) and treatment as the main effects. When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores. However, dexamethasone had a more beneficial effect on BAL cytology.

摘要

本研究旨在比较口服泼尼松龙和肌肉注射地塞米松对患有慢性阻塞性肺病的马匹在环境控制下的疗效。共有16匹年龄在8至20岁之间的患慢性阻塞性肺病的马匹纳入本研究。在第0天（治疗前）、第13天（治疗后）和第30天进行了全面检查。评估了临床变量、动脉血气、黏液评分和隆突评估（内镜检查期间）以及支气管肺泡灌洗（BAL）细胞学分析。这些马匹被随机分配接受口服泼尼松龙（1mg/kg）或肌肉注射地塞米松（0.1mg/kg）。对动物进行临床评分并评估黏液积聚情况。结果采用重复测量方差分析，以时间（治疗天数）和治疗作为主要效应进行分析。当与环境控制相结合时，泼尼松龙和地塞米松治疗对慢性阻塞性肺病评分、血气和内镜评分有相似的效果。然而，地塞米松对支气管肺泡灌洗细胞学有更有益的影响。