Feng Yanmei, Wang Jian, Yin Shankai
Department of Otolaryngology, No 6 People's Hospital, Shanghai JiaoTong University Shanghai, China.
Acta Otolaryngol. 2007 Feb;127(2):143-8. doi: 10.1080/00016480600740613.
General anesthesia induced by sodium pentobarbital reduces temporal resolution as represented by an increase in the threshold of gap-evoked auditory responses in guinea pigs.
To explore the potential impact of general anesthesia by sodium pentobarbital (PB), a common anesthetic used in animal research, on gap-evoked responses.
The evoked potentials in response to gaps formed by bursts of broadband noise were recorded from electrodes implanted in the inferior colliculus (IC) and the auditory cortex (AC) of guinea pigs. The gap responses were compared in three conditions: unanesthetized and anesthetized with two doses of sodium pentobarbital (40 mg/kg and 20 mg/kg).
PB increased the gap response thresholds, especially when applied at the higher dose. The threshold shift induced by PB was greater in the AC than in the IC. In addition, the higher dose of PB significantly increased the gap response latency in both IC and AC, and decreased response amplitude in IC only.
戊巴比妥钠诱导的全身麻醉会降低时间分辨率，这表现为豚鼠间隙诱发听觉反应阈值的升高。
探讨动物研究中常用的麻醉剂戊巴比妥钠（PB）全身麻醉对间隙诱发反应的潜在影响。
从植入豚鼠下丘（IC）和听觉皮层（AC）的电极记录对宽带噪声脉冲形成的间隙的诱发电位。在三种情况下比较间隙反应：未麻醉以及用两种剂量的戊巴比妥钠（40mg/kg和20mg/kg）麻醉。
PB提高了间隙反应阈值，尤其是高剂量应用时。PB诱导的阈值变化在AC中比在IC中更大。此外，高剂量的PB显著增加了IC和AC中的间隙反应潜伏期，并且仅降低了IC中的反应幅度。
