Glad H, Vainer B, Buchwald C, Petersen B L, Theilgaard S A, Bonvin P, Lajer C, Jakobsen J
Department of Otolaryngology, Rigshospitalet, Copenhagen.
Acta Otolaryngol. 2007 Mar;127(3):292-9. doi: 10.1080/00016480600818138.
Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor in young males, with a non-negligible potential for recurrence. Preoperative embolization is a safe procedure that diminishes the peroperative blood loss and the need for blood transfusion. The endoscopic approach was used with good results in JNA stage I and II (Chandler).
To estimate the incidence rate of JNA in the Danish population and to describe symptoms and treatment.
This was a national retrospective cohort study. All cases of JNA diagnosed in Denmark from 1981 to 2003 were identified. Data were extracted from medical records.
Forty-five male (no female) JNA cases were identified. In 43 cases, clinical data were recovered. Median age was 15 years. The incidence rate in Denmark was 0.4 cases per million inhabitants per year and 3.7 cases per million males (aged 10-24) per year. All patients underwent surgery, and the endoscopic approach was increasingly being used. The embolization procedure proved to be safe and decreased the intraoperative blood loss statistically to 650 ml in the embolized group from an average of 1200 ml in the non-embolized group (p<0.05). Similarly, the need for peroperative blood transfusion was reduced (p<0.005). The primary recurrence rate was 23% and no patients died.
青少年鼻咽血管纤维瘤（JNA）是一种在年轻男性中罕见的肿瘤，具有不可忽视的复发可能性。术前栓塞是一种安全的操作，可减少术中失血及输血需求。对于I期和II期（钱德勒分期）的JNA，采用内镜手术方法取得了良好效果。
评估丹麦人群中JNA的发病率，并描述其症状和治疗方法。
这是一项全国性回顾性队列研究。确定了1981年至2003年在丹麦诊断出的所有JNA病例。从病历中提取数据。
共确定了45例男性（无女性）JNA病例。43例患者的临床数据可获取。中位年龄为15岁。丹麦的发病率为每年每百万居民0.4例，每年每百万男性（10 - 24岁）3.7例。所有患者均接受了手术，且越来越多地采用内镜手术方法。栓塞操作被证明是安全的，并且在统计学上使栓塞组的术中失血量从非栓塞组的平均1200毫升降至650毫升（p<0.05）。同样，术中输血需求也减少了（p<0.005）。原发性复发率为23%，无患者死亡。
