Frandsen N J, Pedersen F
Hvidovre Hospital, Mineralmetabolisk Forskningsgruppe, kardiologisk afdeling, København.
Ugeskr Laeger. 1992 Jan 20;154(4):188-90.
Our knowledge about magnesium in health and disease has increased during the past ten years. Many authors have demonstrated possible magnesium depletion in the population as a whole and particularly among cardiac patients receiving diuretics. Evidence suggests that this magnesium depletion may play a role in the development of arteriosclerosis. It has been demonstrated that long term supplementation of the diet with magnesium reduces the frequency of heart disease. However, the matter is still not proven. It is postulated further that magnesium depletion aggravates the outcome of acute myocardial infarct and has a tendency to provoke arrhythmia. Finally, it has been shown that the potassium depletion frequently observed among cardiac patients may actually arise from magnesium depletion. On this basis, many authors have employed magnesium therapy in various cardiac diseases. Some authors have demonstrated that magnesium therapy reduces the mortality in AMI patients. These studies are, however, too few and too limited to be conclusive. In order to investigate this question, an international multicentre trial (ISIS-4) will be conducted to investigate the influence of magnesium therapy on the mortality after acute myocardial infarction.
在过去十年中，我们对镁在健康与疾病方面的认识有所增加。许多作者已证明，总体人群中可能存在镁缺乏的情况，尤其是在接受利尿剂治疗的心脏病患者中。有证据表明，这种镁缺乏可能在动脉粥样硬化的发展中起作用。已证实长期在饮食中补充镁可降低心脏病的发病频率。然而，此事仍未得到证实。进一步推测，镁缺乏会加重急性心肌梗死的后果，并倾向于引发心律失常。最后，已表明在心脏病患者中经常观察到的钾缺乏实际上可能源于镁缺乏。基于此，许多作者已在各种心脏病中采用镁疗法。一些作者已证明镁疗法可降低急性心肌梗死患者的死亡率。然而，这些研究数量太少且范围有限，无法得出结论。为了研究这个问题，将进行一项国际多中心试验（ISIS - 4），以调查镁疗法对急性心肌梗死后死亡率的影响。
