Saunderson Rebecca B, Yu Bing, Trent Ronald J A, Pamphlett Roger
Department of Pathology, University of Sydney, Sydney, Australia.
Amyotroph Lateral Scler. 2007 Feb;8(1):26-30. doi: 10.1080/17482960600864009.
Enteroviruses have been suspected to play a part in the pathogenesis of sporadic motor neuron disease (SMND). Intercellular adhesion molecule type-1 (ICAM1) and coxsackie and adenovirus receptor (CAR) act as receptors for a number of enteroviruses. We therefore examined the viral binding domains of ICAM1 and CAR to see if any changes could be found that might predispose to enteroviral infections. Single nucleotide polymorphisms in the ICAM1 viral binding domain, the adjacent intron and a region implicated in other neurological disorders, as well as the CAR viral binding regions in exons 2-5, were compared in 139 SMND patients and 139 matched controls. The distribution of the polymorphisms was similar in both groups. Therefore, based on linkage disequilibrium and genotype it is unlikely that either ICAM1 or CAR is implicated in SMND.
人们怀疑肠道病毒在散发性运动神经元病（SMND）的发病机制中起作用。细胞间黏附分子-1（ICAM1）以及柯萨奇病毒和腺病毒受体（CAR）作为多种肠道病毒的受体。因此，我们检查了ICAM1和CAR的病毒结合域，看看是否能发现任何可能易患肠道病毒感染的变化。在139例SMND患者和139例匹配对照中，比较了ICAM1病毒结合域、相邻内含子以及与其他神经系统疾病相关区域的单核苷酸多态性，以及外显子2 - 5中CAR病毒结合区域的单核苷酸多态性。两组中多态性的分布相似。因此，基于连锁不平衡和基因型，ICAM1或CAR不太可能与SMND有关。
