Tarpey I, Davis P J, Sondermeijer P, van Geffen C, Verstegen I, Schijns V E J C, Kolodsick Jill, Sundick R
Intervet UK, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK.
Avian Pathol. 2007 Feb;36(1):69-74. doi: 10.1080/03079450601113159.
As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge.
随着马立克氏病病毒不断向更高毒力进化，未来将需要更有效的疫苗。我们从火鸡疱疹病毒（HVT）中表达鸡白细胞介素-2（IL-2），试图提高HVT作为抗马立克氏病疫苗的效力。重组IL-2/HVT用于胚内接种是安全的，尽管与亲本HVT毒株相比，它在鸡体内的复制较少。IL-2的表达增强了针对HVT的中和抗体反应，但并未增强对强毒马立克氏病病毒攻击的保护作用。
