Derosa Giuseppe, Cicero Arrigo F G, Scalise Filippo, Avanzini Maria A, Tinelli Carmine, Piccinni Mario N, Peros Emmanouil, Geroldi Diego, Fogari Elena, D'Angelo Angela
Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
Endothelium. 2007 Jan-Feb;14(1):45-51. doi: 10.1080/10623320601177064.
The authors hypothesized that matrix metalloproteinase (MMP)-2, -9, and tissue inhibitor metalloproteinase (TIMP)-1, -2 would be abnormal in acute coronary syndromes (ACSs). MMP-2, -9, and TIMP-1, -2 plasma levels were measured in diabetic patients with ACSs compared to nondiabetic patients with ACSs. A total of 46 diabetic and 78 nondiabetic patients with ACSs were enrolled. The following parameters were measured: body mass index (BMI), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Significant HbA1c, FPG, FPI, HOMA index, DBP, Tg, Hct, and Fg increases were present in the diabetic group with ACSs, whereas hs-CRP was lower in these patients compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients with ACSs compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event.
作者推测，基质金属蛋白酶（MMP）-2、-9以及组织金属蛋白酶抑制剂（TIMP）-1、-2在急性冠脉综合征（ACS）中会出现异常。研究测定了患有ACS的糖尿病患者与非糖尿病患者的MMP-2、-9以及TIMP-1、-2血浆水平。共纳入了46例患有ACS的糖尿病患者和78例患有ACS的非糖尿病患者。测量了以下参数：体重指数（BMI）、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、空腹血浆胰岛素（FPI）、稳态模型评估指数（HOMA指数）、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（Tg）、脂蛋白（a）[Lp（a）]、纤溶酶原激活物抑制剂-1（PAI-1）、同型半胱氨酸（Hct）、纤维蛋白原（Fg）、高敏C反应蛋白（hs-CRP）以及MMP-2、MMP-9、TIMP-1和TIMP-2的血浆水平。患有ACS的糖尿病组患者的HbA1c、FPG、FPI、HOMA指数、DBP、Tg、Hct和Fg显著升高，而与患有ACSs的非糖尿病患者相比，这些患者的hs-CRP较低。与患有ACS的非糖尿病患者相比，患有ACS的糖尿病患者的MMP-9、TIMP-1和TIMP-2血浆水平更高。患有ACS的糖尿病患者的MMP-9、TIMP-1和TIMP-2血浆水平升高，这可能反映了急性事件期间糖尿病患者细胞外基质代谢异常。
