Lee Seung Won, Song Kyoung Eun, Shin Dong Sun, Ahn Sung Min, Ha Eun Suk, Kim Dae Jung, Nam Moon Suk, Lee Kwan-Woo
Department of Endocrinology and Metabolism, Ajou University School of Medicine, San-5 Wonchon Dong, Yongtong Gu,443-721, Suwon, South Korea.
Diabetes Res Clin Pract. 2005 Aug;69(2):175-9. doi: 10.1016/j.diabres.2004.12.010.
In vivo and in vitro experimental findings indicate that the hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase (MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover.
We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age-matched controls. In addition, we determined the plasma levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and high sensitive(hs) C-reactive protein (CRP) in both groups.
Plasma MMP-2, TIMP-1, and hs-CRP concentrations were significantly elevated in diabetic patients as compared to the control subjects (p<0.05). Plasma levels of MMP-2, MMP-9, TIMP-1, VCAM-1, ICAM-1, and hs-CRP were found not to be significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations.
Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
体内和体外实验结果表明，高血糖的糖尿病环境可诱导基质金属蛋白酶（MMP）基因表达改变，并导致血管基质稳态失衡。我们检测了参与细胞外基质周转的酶和抑制剂的血浆水平。
我们测量了80例无尿毒症的2型糖尿病患者和80例年龄匹配的对照组中MMP-2、MMP-9和金属蛋白酶组织抑制剂1（TIMP-1）的血浆浓度。此外，我们还测定了两组中细胞间黏附分子1（ICAM-1）、血管细胞黏附分子1（VCAM-1）和高敏（hs）C反应蛋白（CRP）的血浆水平。
与对照组相比，糖尿病患者血浆MMP-2、TIMP-1和hs-CRP浓度显著升高（p<0.05）。发现血浆MMP-2、MMP-9、TIMP-1、VCAM-1、ICAM-1和hs-CRP水平与年龄、糖尿病病程、血压或血脂浓度无显著相关性。
2型糖尿病患者血浆MMP-2、TIMP-1和hs-CRP浓度显著升高。
