Mau Marjorie K, West Margaret R, Shara Nawar M, Efird Jimmy T, Alimineti Kavitha, Saito Erin, Sugihara Jared, Ng Roland
Department of Native Hawaiian Health, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI 96813, USA.
Ethn Health. 2007 Apr;12(2):111-27. doi: 10.1080/13557850601081720.
To examine the association between key susceptibility factors and measures of chronic kidney disease in Asian American and Native Hawaiian participants enrolled in the Hawai'i site of the national Kidney Early Evaluation Program (KEEP-2) study community screening program.
In 2001-2003, 793 participants from five ethnic groups (Japanese, Native Hawaii an, Chinese, Filipino and Caucasian) were enrolled in the Hawai'i KEEP-2 program. Odds ratios were used as the measure of association and were computed using unconditional logistic regression. Renal susceptibility factors for chronic kidney disease were included in a multivariable model if found to be statistically significant in univariate analysis. The proportion of Hawai'i KEEP-2 study participants manifesting various clinical characteristics were compared by ethnicity with Japanese as the referent group.
Significant ethnic differences in the occurrence of chronic kidney disease were found, with Japanese having the lowest occurrence of chronic kidney disease (18%) and Native Hawaiians the highest (40%). Within each ethnic group, the occurrence of chronic kidney disease was associated with a different ethnic-specific clustering of susceptibility factors. Hypertension was associated with chronic kidney disease among four of the five ethnic groups: Japanese, Caucasian, Native Hawaiian and Filipino. Overweight was associated with a decreased occurrence of chronic kidney disease among Caucasians, while diabetes and lower educational attainment were associated with increased occurrence of chronic kidney disease among Native Hawaiians. For Filipinos, diabetes and age 65 years and older were both associated with an increased occurrence for chronic kidney disease while lower educational attainment was associated with a reduced occurrence of chronic kidney disease. Among Chinese, no factors were significantly associated with chronic kidney disease, although trends for all factors paralleled those of the overall study group.
The occurrence of chronic kidney disease in the Hawai'i KEEP-2 study was nearly fourfold greater compared with the general US population. The clustering of susceptibility factors for chronic kidney disease occurrence was found to differ for all five ethnic groups.
在参加全国肾脏早期评估项目（KEEP - 2）夏威夷站点社区筛查项目的亚裔美国人和夏威夷原住民参与者中，研究关键易感因素与慢性肾脏病指标之间的关联。
2001年至2003年，来自五个种族群体（日本人、夏威夷原住民、华人、菲律宾人和白种人）的793名参与者参加了夏威夷KEEP - 2项目。比值比用作关联度量，并使用无条件逻辑回归进行计算。如果在单变量分析中发现慢性肾脏病的肾脏易感因素具有统计学意义，则将其纳入多变量模型。以日本人为参照组，按种族比较了表现出各种临床特征的夏威夷KEEP - 2研究参与者的比例。
发现慢性肾脏病的发生率存在显著的种族差异，其中日本人慢性肾脏病发生率最低（18%），夏威夷原住民最高（40%）。在每个种族群体中，慢性肾脏病的发生与不同种族特异性的易感因素聚集有关。高血压与五个种族群体中的四个群体（日本人、白种人、夏威夷原住民和菲律宾人）的慢性肾脏病有关。超重与白种人慢性肾脏病发生率降低有关，而糖尿病和低教育程度与夏威夷原住民慢性肾脏病发生率增加有关。对于菲律宾人，糖尿病和65岁及以上年龄均与慢性肾脏病发生率增加有关，而低教育程度与慢性肾脏病发生率降低有关。在华人中，没有因素与慢性肾脏病显著相关，尽管所有因素的趋势与整个研究组的趋势相似。
夏威夷KEEP - 2研究中慢性肾脏病的发生率比美国普通人群高出近四倍。发现所有五个种族群体慢性肾脏病发生的易感因素聚集情况不同。
