Isoğlu-Alkaç Ummühan, Kedzior Karina, Keskindemirci Gonca, Ermutlu Numan, Karamursel Sacit
Department of Physiology, Istanbul University, Capa-Istanbul, Turkey.
Int J Neurosci. 2007 Feb;117(2):259-73. doi: 10.1080/00207450500534118.
The purpose of this study was to investigate the response properties of event related potentials to unimodal and bimodal stimulations. The amplitudes of N1 and P2 were larger during bimodal evoked potentials (BEPs) than auditory evoked potentials (AEPs) in the anterior sites and the amplitudes of P1 were larger during BEPs than VEPs especially at the parieto-occipital locations. Responses to bimodal stimulation had longer latencies than responses to unimodal stimulation. The N1 and P2 components were larger in amplitude and longer in latency during the bimodal paradigm and predominantly occurred at the anterior sites. Therefore, the current bimodal paradigm can be used to investigate the involvement and location of specific neural generators that contribute to higher processing of sensory information. Moreover, this paradigm may be a useful tool to investigate the level of sensory dysfunctions in clinical samples.
本研究的目的是调查事件相关电位对单峰和双峰刺激的反应特性。在前部位点,双峰诱发电位(BEP)期间N1和P2的波幅大于听觉诱发电位(AEP),在BEP期间P1的波幅大于视觉诱发电位(VEP),尤其是在顶枕部位置。对双峰刺激的反应潜伏期比对单峰刺激的反应潜伏期更长。在双峰范式中,N1和P2成分的波幅更大且潜伏期更长,主要出现在前部位点。因此,当前的双峰范式可用于研究有助于感觉信息高级处理的特定神经发生器的参与情况和位置。此外,该范式可能是研究临床样本中感觉功能障碍程度的有用工具。