深部脑刺激与神经心理学家的作用。

Deep brain stimulation and the role of the neuropsychologist.

作者信息

Okun Michael S, Rodriguez Ramon L, Mikos Ania, Miller Kimberly, Kellison Ida, Kirsch-Darrow Lindsey, Wint Dylan P, Springer Utaka, Fernandez Hubert H, Foote Kelly D, Crucian Gregory, Bowers Dawn

机构信息

Department of Neurology, Movement Disorders Center, University of Florida, Gainesville, FL 32610, USA.

出版信息

Clin Neuropsychol. 2007 Jan;21(1):162-89. doi: 10.1080/13825580601025940.

DOI:10.1080/13825580601025940

PMID:17366283

Abstract

Deep brain stimulation (DBS) now plays an important role in the treatment of Parkinson's disease, tremor, and dystonia. DBS may also have a role in the treatment of other disorders such as obsessive-compulsive disorder, Tourette's syndrome, and depression. The neuropsychologist plays a crucial role in patient selection, follow-up, and management of intra-operative and post-operative effects (Pillon, 2002; Saint-Cyr & Trepanier, 2000). There is now emerging evidence that DBS can induce mood, cognitive, and behavioral changes. These changes can have dramatic effects on patient outcome. There have been methodological problems with many of the studies of DBS on mood, cognition, and behavior. The neuropsychologist needs to be aware of these issues when following up patients, and constructing future studies. Additionally, this article will review all aspects of the DBS procedure that can result in mood, cognitive, and behavioral effects and what role(s) the neuropsychologist should play in screening and follow-up.

摘要

深部脑刺激（DBS）目前在帕金森病、震颤和肌张力障碍的治疗中发挥着重要作用。DBS在其他疾病如强迫症、图雷特综合征和抑郁症的治疗中可能也有作用。神经心理学家在患者选择、随访以及术中及术后效果的管理方面起着关键作用（皮隆，2002年；圣西尔和特雷帕尼尔，2000年）。现在有新出现的证据表明，DBS可诱发情绪、认知和行为改变。这些改变会对患者的治疗结果产生显著影响。许多关于DBS对情绪、认知和行为影响的研究存在方法学问题。神经心理学家在随访患者和开展未来研究时需要意识到这些问题。此外，本文将综述DBS手术中可能导致情绪、认知和行为影响的各个方面，以及神经心理学家在筛查和随访中应发挥的作用。