Donovan Neila J, Kendall Diane L, Moore Anna Bacon, Rosenbek John C, Rothi Leslie J Gonzalez
VA RR&D Brain Rehabilitation Research Center, Gainsville, Florida 32608, USA.
Clin Neuropsychol. 2007 Jan;21(1):190-203. doi: 10.1080/13854040600634584.
The purpose of this case study was to examine the integrity of cognitive skills, language usage, and language structure components in a patient with corticobasal degeneration (CBD). CBD is a levadopa-nonresponsive, degenerative neurologic movement disorder that is generally accompanied by cognitive (frontal executive dysfunction, dementia) and linguistic (aphasia) disorders. However, no one has reported on social language usage deficits in cases of CBD. The reported frontal executive dysfunction found in CBD led us to expect social language usage deficits in the present case study. Consistent with the literature, the patient demonstrated motor, cognitive (severe apraxia, frontal executive deficits, dementia), and linguistic deficits (aphasia). However she also demonstrated significantly abnormal social language usage previously unreported in the literature.
本病例研究的目的是检查一名患有皮质基底节变性（CBD）患者的认知技能、语言运用和语言结构成分的完整性。CBD是一种对左旋多巴无反应的退行性神经运动障碍，通常伴有认知（额叶执行功能障碍、痴呆）和语言（失语症）障碍。然而，尚无关于CBD病例中社交语言运用缺陷的报道。CBD中报告的额叶执行功能障碍使我们预期在本病例研究中会出现社交语言运用缺陷。与文献一致，该患者表现出运动、认知（严重失用症、额叶执行功能缺陷、痴呆）和语言缺陷（失语症）。然而，她还表现出文献中先前未报道的明显异常的社交语言运用。
