Hall Håkan, Lawyer Glenn, Sillén Anna, Jönsson Erik G, Agartz Ingrid, Terenius Lars, Arnborg Stefan
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
World J Biol Psychiatry. 2007;8(1):12-22. doi: 10.1080/15622970600892004.
A number of different gene polymorphisms have been found to dispose for the development of schizophrenia. However, no single gene polymorphism is sufficient for the precipitation of schizophrenia. Swedish psychosis patients (n=103) and control subjects (n=89) were analyzed for 36 single nucleotide polymorphisms in 30 candidate genes for schizophrenia. Evidence of association was analyzed with Bayesian statistical methods. Variants in the genes coding for dopamine-D2 receptor, brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), neuregulin 1, reelin and synapsin 3 showed association with schizophrenia, although few subjects were found in the minority allele for the two latter variants. The six gene variants, all with suspected connection to schizophrenia, were found to be risk factors when considered in combination, but not separately. The results indicate that the Bayesian statistical method gives additional possibilities in the search for risk factors for schizophrenia or other complex disorders.
人们发现许多不同的基因多态性与精神分裂症的发生有关。然而，没有单一的基因多态性足以引发精神分裂症。对瑞典的精神病患者（n = 103）和对照受试者（n = 89）进行了分析，检测了30个精神分裂症候选基因中的36个单核苷酸多态性。采用贝叶斯统计方法分析关联证据。编码多巴胺 - D2受体、脑源性神经营养因子（BDNF）、神经肽Y（NPY）、神经调节蛋白1、Reelin和突触素3的基因变体与精神分裂症有关联，尽管后两种变体的少数等位基因中发现的受试者较少。这六个基因变体都与精神分裂症存在疑似关联，当综合考虑时被发现是危险因素，但单独考虑时并非如此。结果表明，贝叶斯统计方法为寻找精神分裂症或其他复杂疾病的危险因素提供了更多可能性。
