Varnäs Katarina, Lawyer Glenn, Jönsson Erik G, Kulle Bettina, Nesvåg Ragnar, Hall Håkan, Terenius Lars, Agartz Ingrid
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Psychiatr Genet. 2008 Aug;18(4):177-83. doi: 10.1097/YPG.0b013e3283050a94.
To investigate associations between brain-derived neurotrophic factor (BDNF) gene polymorphisms and regional frontal cortical thickness and volume in patients with schizophrenia and healthy control participants.
BDNF genotyping was performed using polymerase chain reaction and pyrosequencing techniques in 96 patients with schizophrenia or schizoaffective disorder and 104 healthy control participants. Cortical morphology was analyzed by processing magnetic resonance brain images with the FreeSurfer software package. General linear model analysis was used to study associations between BDNF variants and cortical thickness in patients and controls, respectively. Regional frontal cortical volumes were defined from automatic cortical parcellations.
For patients with schizophrenia, there was an association between the BDNF -633 T/A polymorphism and thickness and volume of distinct subregions of the prefrontal cortex. Data indicated trends toward genotypic associations between the BDNF 270 C/T and 11757 G/C polymorphisms and the volume of specific frontal lobe regions in patients with schizophrenia. Among controls, there were no significant associations between BDNF polymorphisms and cortical thickness. Trends toward genotypic associations between BDNF polymorphisms and volumes of some frontal lobe regions for control participants were observed, although these differences did not reach statistical significance.
Polymorphisms in the BDNF gene may be associated with variation in frontal lobe morphology. Associations seem to be stronger in patients with schizophrenia than in healthy controls.
研究精神分裂症患者及健康对照者脑源性神经营养因子（BDNF）基因多态性与额叶皮质厚度及体积之间的关联。
采用聚合酶链反应和焦磷酸测序技术对96例精神分裂症或分裂情感性障碍患者及104名健康对照者进行BDNF基因分型。使用FreeSurfer软件包处理磁共振脑图像，分析皮质形态。分别采用一般线性模型分析研究BDNF变异与患者及对照者皮质厚度之间的关联。通过自动皮质分区确定额叶皮质区域体积。
对于精神分裂症患者，BDNF -633 T/A多态性与前额叶皮质不同亚区域的厚度及体积之间存在关联。数据表明，BDNF 270 C/T和11757 G/C多态性与精神分裂症患者特定额叶区域体积之间存在基因型关联趋势。在对照者中，BDNF多态性与皮质厚度之间无显著关联。观察到对照者中BDNF多态性与一些额叶区域体积之间存在基因型关联趋势，尽管这些差异未达到统计学显著性。
BDNF基因多态性可能与额叶形态变异有关。这种关联在精神分裂症患者中似乎比在健康对照者中更强。
