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先天性心脏内分流畸形手术矫正后儿童的心肌性能指数

The myocardial performance index in children after surgical correction of congenital malformations with intracardiac shunt.

作者信息

Zacharska-Kokot Ewa

机构信息

II Katedra i Klinika Kardiochirurgii i Chirurgii Ogólnej Dzieci AM, ul. Działdowska 1, 01-184 Warszawa.

出版信息

Kardiol Pol. 2007 Feb;65(2):143-50; discussion 151-2.

Abstract

BACKGROUND

The lack of a simple and clinically useful method of myocardial function assessment makes it difficult to monitor patients after repair of congenital cardiac malformations. The myocardial performance index (MPI) introduced in 1995 by Chuwa Tei may help to precisely follow the course of postoperative myocardial function disturbances.

AIM

To assess the usefulness of MPI for cardiac function evaluation following surgical correction of congenital defects performed in cardiopulmonary bypass and to evaluate it's prognostic value.

METHODS

This prospective study involved 73 children who underwent surgery for simple defects with intracardiac shunt--34 children with atrial septal defect (ASD) and 39 with ventricular septal defect (VSD). In the examined patient group, MPI and the parameters of cardiac index were measured in the early postoperative period. Then the results were correlated with congenital defect severity and postoperative course. The control group consisted of 77 healthy children.

RESULTS

In the control group of healthy children, mean values of the right (RVMPI) and the left ventricular MPI (LVMPI) were 0.32+/-0.06 and 0.33+/-0.05, respectively. In children after ASD correction, MPI was elevated only for the right ventricle (mean value of 0.41+/-0.07). Meanwhile in children operated on for VSD, both the RVMPI and LVMPI values increased postoperatively. RVMPI reached a peak value on the 2nd postoperative day (0.48+/-0.20) while LVMPI reached a peak value between the 3rd and 5th day after surgery (0.49+/-0.10). A significant and strong correlation between severity of VSD and MPI values was observed. A marked correlation between MPI calculated on the 1st postoperative day and the course after surgery was also noted.

CONCLUSIONS

The MPI is a precise tool assessing both systolic and diastolic ventricular performance in the early postoperative period following surgical correction of a congenital defect with intracardiac shunt and is also a useful predictive factor of the postoperative course.

摘要

背景

缺乏一种简单且临床实用的心肌功能评估方法,使得先天性心脏畸形修复术后患者的监测变得困难。1995年由Chuwa Tei提出的心肌性能指数(MPI)可能有助于精确跟踪术后心肌功能障碍的进程。

目的

评估MPI在体外循环下进行先天性缺陷手术矫正后对心脏功能评估的有用性,并评估其预后价值。

方法

这项前瞻性研究纳入了73例接受简单心内分流缺陷手术的儿童,其中34例为房间隔缺损(ASD)儿童,39例为室间隔缺损(VSD)儿童。在受检患者组中,术后早期测量MPI和心脏指数参数。然后将结果与先天性缺陷严重程度和术后病程相关联。对照组由77名健康儿童组成。

结果

在健康儿童对照组中,右心室MPI(RVMPI)和左心室MPI(LVMPI)的平均值分别为0.32±0.06和0.33±0.05。在ASD矫正后的儿童中,MPI仅右心室升高(平均值为0.41±0.07)。同时,在接受VSD手术的儿童中,RVMPI和LVMPI值术后均升高。RVMPI在术后第2天达到峰值(0.48±0.20),而LVMPI在术后第3至5天达到峰值(0.49±0.10)。观察到VSD严重程度与MPI值之间存在显著且强烈的相关性。术后第1天计算的MPI与术后病程之间也存在明显相关性。

结论

MPI是评估先天性心内分流缺陷手术矫正术后早期心室收缩和舒张功能的精确工具,也是术后病程的有用预测因素。

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