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手术修复后小的残余室间隔缺损的自然闭合

Spontaneous closure of small residual ventricular septal defects after surgical repair.

作者信息

Dodge-Khatami Ali, Knirsch Walter, Tomaske Maren, Prêtre René, Bettex Dominique, Rousson Valentin, Bauersfeld Urs

机构信息

Division of Congenital Cardiovascular Surgery, University Children's Hospital, Zürich, Switzerland.

出版信息

Ann Thorac Surg. 2007 Mar;83(3):902-5. doi: 10.1016/j.athoracsur.2006.09.086.

Abstract

BACKGROUND

Residual shunts may be detected by intraoperative or postoperative echocardiography after surgical closure of a ventricular septal defect (VSD). The hemodynamic relevance and rate of late closure are unknown.

METHODS

Between 1994 and 2005, 198 consecutive patients underwent surgical correction of an isolated VSD (n = 100), tetralogy of Fallot (n = 52) or atrioventricular septal defect (n = 46). Intraoperative transesophageal echocardiography (TEE) was routine, and postoperative transthoracic echocardiography was performed in the intensive care unit, at hospital discharge, and during follow-up. Residual defects were graded as absent, between 1 and 2 mm, or greater than 2 mm.

RESULTS

Shunt-related discrepancy was observed between intraoperative TEE and intensive care unit transthoracic echocardiographic findings; significantly so after Fallot repair (p < 0.0001). After discharge, 83% of all residual defects less than 2 mm closed. Of nine residual defects greater than 2 mm, only three closed after a median follow-up of 3.1 years. In patients with residual shunts, they were hemodynamically insignificant, required no medication, and no endocarditis was noted. At last follow-up, there was no significant difference between the percentage of residual shunts among the three groups (p = 0.135).

CONCLUSIONS

Postsurgical residual VSDs less than 2 mm closed spontaneously in the majority within a year. Defects greater than 2 mm are unlikely to close spontaneously. Residual shunts after atrioventricular septal defect repair almost always close, whereas one third will remain open after Fallot or isolated VSD repair. At midterm follow-up, residual shunts remained hemodynamically and clinically irrelevant. Revision of a residual defect greater than 2 mm on cardiopulmonary bypass at initial repair, guided by TEE, may spare late redo surgery and lifelong antibiotic prophylaxis.

摘要

背景

室间隔缺损(VSD)手术闭合后,术中或术后超声心动图可能检测到残余分流。其血流动力学相关性及晚期闭合率尚不清楚。

方法

1994年至2005年期间,198例连续患者接受了单纯室间隔缺损(n = 100)、法洛四联症(n = 52)或房室间隔缺损(n = 46)的手术矫正。术中经食管超声心动图(TEE)为常规检查,术后在重症监护病房、出院时及随访期间进行经胸超声心动图检查。残余缺损分为无、1至2毫米之间或大于2毫米。

结果

术中TEE与重症监护病房经胸超声心动图检查结果之间观察到分流相关差异;法洛四联症修复术后差异尤为显著(p < 0.0001)。出院后,所有小于2毫米的残余缺损中有83%闭合。在9例大于2毫米的残余缺损中,中位随访3.1年后仅有3例闭合。在有残余分流的患者中,分流在血流动力学上无显著意义,无需药物治疗,且未发现心内膜炎。在最后一次随访时,三组之间残余分流的百分比无显著差异(p = 0.135)。

结论

术后小于2毫米的残余室间隔缺损在大多数情况下会在一年内自发闭合。大于2毫米的缺损不太可能自发闭合。房室间隔缺损修复术后的残余分流几乎总会闭合,而法洛四联症或单纯室间隔缺损修复术后三分之一的分流会持续开放。在中期随访中,残余分流在血流动力学和临床上仍无显著意义。在初次修复时,在TEE引导下对大于2毫米的残余缺损进行体外循环下修补,可能避免晚期再次手术和终身抗生素预防。

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