Kontoyiannis Dimitrios P
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Clin Infect Dis. 2007 Apr 15;44(8):1089-90. doi: 10.1086/512817. Epub 2007 Mar 2.
The number of reported cases of zygomycosis in patients with diabetes mellitus in developed countries has decreased since the 1990s, despite the rapid increase in the prevalence of diabetic patients in the Western world. Although prospective population-based studies need to better document this phenomenon, which may have a complex explanation, here I propose the hypothesis that widespread use of statins in patients with diabetes underlies such a trend. Statins have been shown to direct inhibitory activity against a range of Zygomycetes molds, both in vitro and in vivo.
自20世纪90年代以来，发达国家糖尿病患者中报告的接合菌病病例数有所下降，尽管西方世界糖尿病患者的患病率迅速上升。虽然基于人群的前瞻性研究需要更好地记录这一现象，其原因可能很复杂，但在此我提出一个假设，即糖尿病患者广泛使用他汀类药物是导致这种趋势的原因。他汀类药物已被证明在体外和体内对一系列接合菌霉菌具有直接抑制活性。
