Kirschner Denise E, Chang Stewart T, Riggs Thomas W, Perry Nicolas, Linderman Jennifer J
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Immunol Rev. 2007 Apr;216:93-118. doi: 10.1111/j.1600-065X.2007.00490.x.
A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in the biological literature regarding each of these scales, no single representation synthesizing this information into a model of the overall immune response as it depends on antigen presentation is available. In this article, we outline an approach for integrating information over relevant biological and temporal scales to generate such a representation for major histocompatibility complex class II-mediated antigen presentation. In addition, we begin to address how such models can be used to answer questions about mechanisms of infection and new strategies for treatment and vaccines.
一个正常运作的免疫系统，尤其是抗原呈递过程，包含了在多个长度和时间尺度上发生的事件。尽管生物学文献中有大量关于这些尺度中每一个的信息，但目前还没有一个将这些信息综合成一个依赖于抗原呈递的整体免疫反应模型的单一表述。在本文中，我们概述了一种在相关生物学和时间尺度上整合信息的方法，以生成这样一种关于主要组织相容性复合体II类介导的抗原呈递的表述。此外，我们开始探讨如何利用这些模型来回答关于感染机制以及治疗和疫苗新策略的问题。
