Tantucci C, Corbeil C, Chasse M, Robatto F M, Nava S, Braidy J, Matar N, Milic-Emili J
Respiratory Division, Hôpital Saint-Luc, Université de Montreal, Quebec, Canada.
Am Rev Respir Dis. 1992 Feb;145(2 Pt 1):355-60. doi: 10.1164/ajrccm/145.2_Pt_1.355.
Using a simple and rapid technique, we studied the flow and volume dependence of the total resistance of the respiratory system (Rrs) in six patients with ARDS. At any given inflation volume, Rrs decreased progressively with increasing flow (V) according to the following hyperbolic function: Rrs = a/V + b, where a and b are constants. At any fixed inflation flow, Rrs increased progressively with increasing inflation volume. The observed flow and volume dependence of Rrs is probably mainly due to the viscoelastic properties of the pulmonary and chest wall tissues. The flow and volume dependence of Rrs found in the patients with ARDS is qualitatively similar to that previously observed in normal anesthetized paralyzed subjects. In ARDS, however, Rrs was considerably greater than in the normal subjects, indicating that besides a low respiratory compliance ARDS is characterized by a high flow resistance. This mainly reflects increased effective flow resistance of the pulmonary and chest wall tissues, although airway resistance is also higher than normal.
我们采用一种简单快速的技术，研究了6例急性呼吸窘迫综合征（ARDS）患者呼吸系统总阻力（Rrs）与流量和容积的关系。在任何给定的充气容积下，Rrs随流量（V）增加而逐渐降低，符合以下双曲线函数：Rrs = a/V + b，其中a和b为常数。在任何固定的充气流量下，Rrs随充气容积增加而逐渐增加。观察到的Rrs对流量和容积的依赖性可能主要归因于肺和胸壁组织的粘弹性特性。ARDS患者中发现的Rrs对流量和容积的依赖性在质量上与先前在正常麻醉的瘫痪受试者中观察到的相似。然而，在ARDS中，Rrs明显高于正常受试者，这表明除了低呼吸顺应性外，ARDS的特征还在于高流量阻力。这主要反映了肺和胸壁组织有效流量阻力的增加，尽管气道阻力也高于正常。
