Heruti Rafi J, Uri Inbal, Arbel Yaron, Swartzon Michael, Galor Shay, Justo Dan
Reuth Medical Center-Sexual Rehabilitation Center, Tel-Aviv, Israel.
J Sex Med. 2007 Mar;4(2):465-71. doi: 10.1111/j.1743-6109.2006.00420.x.
Although erectile dysfunction (ED) might be associated with coronary heart disease (CHD), there is no evidence it predicts poor cardiovascular prognosis. On the other hand, an abnormal heart rate profile during exercise stress testing predicts poor cardiovascular prognosis in high-risk patients, such as diabetic men, even in the absence of CHD.
In order to study if ED predicts poor cardiovascular prognosis in high-risk patients, we examined the association between ED and heart rate profile during exercise stress testing in diabetic men with no CHD.
Erectile dysfunction severity, exercise capacity during exercise stress testing, and heart rate decrease after exercise stress testing.
A retrospective study. The medical charts of diabetic men with vascular ED from a single-sex clinic were reviewed, as well as the medical charts of body mass index (BMI)- and age-matched diabetic men without ED going through routine check-ups. All men underwent routine treadmill stress testing according to the Bruce protocol in order to characterize heart rate profile during exercise. The Sexual Health Inventory for Men (SHIM) questionnaire was used to characterize ED.
Included were 18 diabetic men with ED (SHIM questionnaire scores 5-21) and 18 diabetic men without ED (SHIM questionnaire scores 22-25), 40 years of age or older. None of the men had signs of coronary insufficiency during exercise treadmill stress testing. Although the two groups did not statistically differ with respect to the mean age, the mean BMI, the prevalence of cardiovascular risk factors, and the mean exercise treadmill stress testing findings, the SHIM questionnaire scores were significantly associated with low metabolic equivalents (r = 0.51, P = 0.03) and delayed heart rate recovery during the first 2 minutes after exercise (r = 0.55, P = 0.018) only among diabetic men with ED.
Erectile dysfunction severity might be associated with poor cardiovascular prognosis in adult diabetic men with no CHD.
虽然勃起功能障碍（ED）可能与冠心病（CHD）相关，但尚无证据表明其可预测不良心血管预后。另一方面，运动负荷试验期间异常的心率变化可预测高危患者（如糖尿病男性）的不良心血管预后，即使在无冠心病的情况下也是如此。
为研究ED是否可预测高危患者的不良心血管预后，我们在无冠心病的糖尿病男性中，检测了ED与运动负荷试验期间心率变化之间的关联。
勃起功能障碍严重程度、运动负荷试验期间的运动能力，以及运动负荷试验后心率下降情况。
一项回顾性研究。回顾了一家单性别诊所中患有血管性ED的糖尿病男性的病历，以及体重指数（BMI）和年龄匹配的无ED且正在接受常规检查的糖尿病男性的病历。所有男性均按照布鲁斯方案进行常规跑步机负荷试验，以确定运动期间的心率变化特征。使用男性性健康量表（SHIM）问卷来确定ED情况。
纳入了18名患有ED的糖尿病男性（SHIM问卷评分5 - 21）和18名无ED的糖尿病男性（SHIM问卷评分22 - 25），年龄均在40岁及以上。在运动跑步机负荷试验期间，所有男性均无冠状动脉供血不足的迹象。虽然两组在平均年龄、平均BMI、心血管危险因素患病率以及平均运动跑步机负荷试验结果方面无统计学差异，但仅在患有ED的糖尿病男性中，SHIM问卷评分与低代谢当量（r = 0.51，P = 0.03）以及运动后前2分钟内心率恢复延迟（r = 0.55，P = 0.018）显著相关。
在无冠心病的成年糖尿病男性中，勃起功能障碍严重程度可能与不良心血管预后相关。
