Vastrik Imre, D'Eustachio Peter, Schmidt Esther, Gopinath Gopal, Croft David, de Bono Bernard, Gillespie Marc, Jassal Bijay, Lewis Suzanna, Matthews Lisa, Wu Guanming, Birney Ewan, Stein Lincoln
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Genome Biol. 2007;8(3):R39. doi: 10.1186/gb-2007-8-3-r39.
Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.
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