Cramer Stewart F, Newcomb Patricia M, Bonfiglio Thomas A
Department of Pathology, Rochester General Hospital, University of Rochester School of Medicine, Rochester, NY 14621, USA.
Hum Pathol. 2007 Apr;38(4):652-5. doi: 10.1016/j.humpath.2007.01.010.
Although precursor lesions are well known for cervical and endometrial neoplasms, precursor lesions are not currently recognized for the most common tumor of the uterus-leiomyomas. Myometrial hyperplasia has been recently described and evaluated by morphometry, but its relationship to uterine leiomyomas has not been systematically explored. Myometrial dysplasia (atypical myometrial hyperplasia) has not been previously recognized. We herein report a case of myometrial dysplasia with immunostains for proliferation marker MIB-1 (Ki-67) and for p53. The paradoxical rarity of myometrial dysplasia is considered in comparison to the striking frequency of uterine leiomyomas.
虽然前驱病变在宫颈癌和子宫内膜肿瘤中广为人知，但目前子宫最常见的肿瘤——平滑肌瘤，却尚未发现前驱病变。最近已有关于子宫肌层增生的描述，并通过形态计量学进行了评估，但其与子宫平滑肌瘤的关系尚未得到系统研究。子宫肌层发育异常（非典型子宫肌层增生）此前尚未被认识到。我们在此报告一例子宫肌层发育异常的病例，并对增殖标志物MIB-1（Ki-67）和p53进行免疫染色。与子宫平滑肌瘤的高发病率相比，子宫肌层发育异常的罕见性显得颇为矛盾。
