Grogan T M, Odom R B, Burgess J H
Arch Dermatol. 1977 Jun;113(6):806-12.
Observations surrounding the clinical manifestations and pathological studies of a neonate who died at 9 weeks of age, indicate that distinctive cutaneous, histopathologic, and ultrastructural findings occur when graft-vs-host reaction (GVHR) complicates combined immune deficiency syndrome (CIDS). The prominence and specificity of the epidermal lesions, particularly a necrotic cell that occurs in association with satellite lymphocytes ("satellite cell necrosis" (SCN)), lead us to recommend that a cutaneous biopsy be performed to facilitate an early definitive diagnosis. Dermatologists can recognize GVHR at the bedside and establish the diagnosis with the pathological findings obtained from the skin biopsy.
对一名9周龄死亡新生儿的临床表现及病理研究观察表明，当移植物抗宿主反应（GVHR）并发联合免疫缺陷综合征（CIDS）时，会出现独特的皮肤、组织病理学及超微结构表现。表皮病变的显著特征及特异性，尤其是与卫星淋巴细胞相关的坏死细胞（“卫星细胞坏死”（SCN）），促使我们建议进行皮肤活检以利于早期明确诊断。皮肤科医生可在床边识别GVHR，并依据皮肤活检的病理结果确诊。
