母血促肾上腺皮质激素释放激素和促肾上腺皮质激素水平作为早产的预测指标。
Maternal serum corticotropin-releasing hormone and ACTH levels as predictive markers of premature labor.
作者信息
Makrigiannakis A, Semmler M, Briese V, Eckerle H, Minas V, Mylonas I, Friese K, Jeschke U
机构信息
Laboratory of Human Reproduction, Department of Obstetrics & Gynecology, Medical School, University of Crete, Heraklion, Greece.
出版信息
Int J Gynaecol Obstet. 2007 May;97(2):115-9. doi: 10.1016/j.ijgo.2007.01.007. Epub 2007 Mar 21.
OBJECTIVE
To investigate whether corticotropin-releasing hormone (CRH) and corticotropin (ACTH) plasma concentrations in women diagnosed with preterm labor are of potential clinical value in the assessment of the risk of preterm birth.
METHOD
Plasma samples of 79 women diagnosed with preterm labor were used in this study. Samples were divided into three groups based on the week of gestation (24th-28th, 29th-32nd, 33rd-37th). CRH and ACTH values were determined by ELISA.
RESULT
Mean maternal peripheral plasma values of CRH and ACTH were significantly higher (p<0.001) in women who were initially diagnosed with preterm labor and finally delivered a preterm birth, compared to women with the same diagnosis but with term birth.
CONCLUSION
CRH and ACTH serum levels in women diagnosed with preterm labor could be used as predictors for the timing of parturition.
目的
探讨诊断为早产的女性血浆促肾上腺皮质激素释放激素（CRH）和促肾上腺皮质激素（ACTH）浓度在评估早产风险方面是否具有潜在临床价值。
方法
本研究使用了79例诊断为早产的女性的血浆样本。样本根据孕周（第24 - 28周、第29 - 32周、第33 - 37周）分为三组。采用酶联免疫吸附测定法（ELISA）测定CRH和ACTH值。
结果
与诊断相同但足月分娩的女性相比，最初诊断为早产且最终早产分娩的女性，其母体外周血CRH和ACTH的平均水平显著更高（p<0.001）。
结论
诊断为早产的女性的CRH和ACTH血清水平可作为分娩时间的预测指标。
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