Berkowitz G S, Lapinski R H, Lockwood C J, Florio P, Blackmore-Prince C, Petraglia F
Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, New York, USA.
Am J Obstet Gynecol. 1996 May;174(5):1477-83. doi: 10.1016/s0002-9378(96)70591-4.
The primary objective of this investigation was to evaluate whether maternal serum corticotropin-releasing factor levels during pregnancy were predictive of spontaneous preterm delivery.
Maternal serum levels of corticotropin-releasing factor and its binding protein were measured from 20 weeks of gestation in a cross-sectional study of 396 asymptomatic women at high risk for preterm delivery.
Gestational age-specific corticotropin-releasing factor levels were not consistently or substantially increased for preterm compared with term deliveries, whether preterm delivery was due to preterm labor or preterm premature rupture of membranes. The binding protein for corticotropin-releasing factor did not vary according to gestational age until term, when it dropped substantially.
Serum corticotropin-releasing factor levels do not appear to be an important predictor of preterm birth in asymptomatic patients who subsequently have either preterm labor or preterm premature rupture of membranes. Nevertheless, the drop in the corticotropin-releasing factor binding protein level at term suggests that the bioavailability of corticotropin-releasing factor increases as parturition approaches.
本研究的主要目的是评估孕期母体血清促肾上腺皮质激素释放因子水平是否可预测自发性早产。
在一项对396名无症状早产高危女性的横断面研究中，从妊娠20周起测量母体血清促肾上腺皮质激素释放因子及其结合蛋白水平。
与足月分娩相比，无论早产是由于早产临产还是胎膜早破，早产时特定孕周的促肾上腺皮质激素释放因子水平并未持续或显著升高。促肾上腺皮质激素释放因子的结合蛋白在足月前随孕周无变化，足月时则大幅下降。
对于随后发生早产临产或胎膜早破的无症状患者，血清促肾上腺皮质激素释放因子水平似乎不是早产的重要预测指标。然而，足月时促肾上腺皮质激素释放因子结合蛋白水平的下降表明，随着分娩临近，促肾上腺皮质激素释放因子的生物利用度增加。
