Szymański Maciej, Barciszewski Jan
Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland.
Acta Biochim Pol. 2007;54(1):51-4. Epub 2007 Mar 20.
The genetic code discovered 40 years ago, consists of 64 triplets (codons) of nucleotides. The genetic code is almost universal. The same codons are assigned to the same amino acids and to the same START and STOP signals in the vast majority of genes in animals, plants, and microorganisms. Each codon encodes for one of the 20 amino acids used in the synthesis of proteins. That produces some redundancy in the code and most of the amino acids being encoded by more than one codon. The two cases have been found where selenocysteine or pyrrolysine, that are not one of the standard 20 is inserted by a tRNA into the growing polypeptide.
40年前发现的遗传密码由64个核苷酸三联体(密码子)组成。遗传密码几乎是通用的。在动物、植物和微生物的绝大多数基因中,相同的密码子被赋予相同的氨基酸以及相同的起始和终止信号。每个密码子编码用于蛋白质合成的20种氨基酸中的一种。这在密码中产生了一些冗余,并且大多数氨基酸由不止一个密码子编码。已经发现了两种情况,即硒代半胱氨酸或吡咯赖氨酸(它们不是标准的20种氨基酸之一)由转运RNA插入到正在生长的多肽中。