Robert-Ebadi H, Boehlen F, de Moerloose P
Unité d'hémostase, Service d'angiologie et d'hémostase, HUG, Genève.
Rev Med Suisse. 2007 Feb 7;3(97):331-2, 334-5.
Thrombophilia may be defined as an acquired or congenital abnormality of hemostasis predisposing to thrombosis. Some of the inherited abnormalities such as factor V Leiden mutation, factor II G20210A mutation as well as deficiencies in antithrombin, protein C and protein S, are already known to be risk factors for venous thromboembolism. This review focuses on the link between these abnormalities and arterial thrombosis. Routine screening for these disorders is not indicated in most cases of arterial complications, but could be useful in some sub-groups of patients, such as young patients, smokers, patients on oral contraception, or those with premature occlusion after revascularization procedures. Anticoagulation rather than antiplatelet therapy may be preferable for these patients.
血栓形成倾向可定义为一种导致血栓形成的后天性或先天性止血异常。一些遗传性异常，如凝血因子V莱顿突变、凝血因子II G20210A突变以及抗凝血酶、蛋白C和蛋白S缺乏，已被确认为静脉血栓栓塞的危险因素。本综述聚焦于这些异常与动脉血栓形成之间的联系。在大多数动脉并发症病例中，不建议进行这些疾病的常规筛查，但在某些亚组患者中可能有用，如年轻患者、吸烟者、口服避孕药的患者或血管重建术后过早闭塞的患者。对于这些患者，抗凝治疗而非抗血小板治疗可能更可取。
