Sakakibara Keitaro, Okano Tetsuya, Kurane Shuji, Kudoh Shouji
Department of First Internal Medicine, Hakujikai Memorial Hospital, 5-11-1 Shikahama, Adachi-ku, Tokyo 123-0864 Japan.
Kekkaku. 2007 Feb;82(2):111-4.
This case is a 56-year old woman. Steroids were being administered perorally after a thymectomy for myasthenia gravis. A fever of 38-39 degrees Celsius appeared during night, an abnormal shadow showed up on a chest X-ray and the patient was hospitalized. Gaffky No. 2 acid-fast bacilli were detected in the patient's sputum and the chest CT showed diffuse granular-like shadow, the patient was diagnosed as miliary tuberculosis and treatment with combined use of INH, RFP, EB, and PZA was started. Subsequently, fever started to subside and the miliary shadow on chest X-ray improved, however, six weeks after the start of treatment, hoarseness and dysphagia appeared. From the cervical CT and cervical angiography findings, the diagnosis of right subclavian artery impending ruptured aneurysm was made. Because the patient's sputum was acid-fast bacilli positive and because the patient had undergone thymectomy, it was decided that it would be difficult to treat her by a thoracotomy again. Therefore, a right subclavian artery stent insertion, right subclavian artery-right common carotid artery bypass creation operation was carried out with the objective of blocking the flow of blood to the aneurysm. The hoarseness and dysphagia improved post-operatively and the patient's progress is being monitored. Tuberculous aneurysms are a rare affection and they are mostly discovered when the autopsy is done, however, this case was diagnosed due to the manifestation of subjective symptoms. While this case was not diagnosed histopathologically, it is envisaged from the clinical progress that this was a tuberculous subclavian aneurysm complicated during the treatment for miliary tuberculosis.
该病例为一名56岁女性。因重症肌无力行胸腺切除术后一直口服类固醇药物。夜间出现38 - 39摄氏度发热,胸部X光检查显示异常阴影,患者因此住院。患者痰液中检测出加夫基2号抗酸杆菌,胸部CT显示弥漫性颗粒状阴影,诊断为粟粒性肺结核,开始联合使用异烟肼、利福平、乙胺丁醇和吡嗪酰胺进行治疗。随后,发热开始消退,胸部X光上的粟粒状阴影有所改善,然而,治疗开始六周后,患者出现声音嘶哑和吞咽困难。根据颈部CT和颈部血管造影结果,诊断为右锁骨下动脉即将破裂的动脉瘤。由于患者痰液抗酸杆菌阳性且已接受胸腺切除术,决定再次开胸手术治疗对其难度较大。因此,进行了右锁骨下动脉支架置入及右锁骨下动脉 - 右颈总动脉搭桥手术,目的是阻断流向动脉瘤的血流。术后声音嘶哑和吞咽困难有所改善,目前正在对患者的病情进展进行监测。结核性动脉瘤是一种罕见疾病,大多在尸检时发现,然而该病例因出现主观症状而得以诊断。虽然该病例未进行组织病理学诊断,但从临床进展推测,这是一例在粟粒性肺结核治疗过程中并发的结核性锁骨下动脉瘤。