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[抗磷脂抗体与抗磷脂综合征:诊断与管理]

[Antiphospholipid antibodies and antiphospholipid syndrome: diagnosis and management].

作者信息

García-García C

机构信息

Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid. España.

出版信息

Actas Dermosifiliogr. 2007 Jan-Feb;98(1):16-23.

Abstract

Antiphospholipid syndrome is an acquired autoimmune thrombophilia that produces significant morbidity and mortality. Its diagnosis requires the presence of antiphospholipid antibodies and clinical manifestations that include thrombotic phenomena and/or recurrent miscarriages. Antiphospholipid antibodies may be detected in many instances, including healthy subjects. Clinical manifestations are varied and may occur in episodes and also appear in other situations. Therefore, it is important to have clear guidelines in order to establish a correct diagnosis, carry out an adequate treatment, and to know which are the prophylactic measures and when they should be undertaken. In this article we explain the most recent diagnostic criteria reviewed in the 11th International Congress on Antiphospholipid Antibodies (Sydney 2004), comment on the varied clinical manifestations with special focus on cutaneous lesions, and review current guidelines for the treatment and prophylaxis of thrombotic and obstetric pathology.

摘要

抗磷脂综合征是一种获得性自身免疫性血栓形成倾向疾病,可导致严重的发病率和死亡率。其诊断需要存在抗磷脂抗体以及包括血栓形成现象和/或反复流产在内的临床表现。在许多情况下都可能检测到抗磷脂抗体,包括健康受试者。临床表现多种多样,可能呈发作性出现,也可能出现在其他情况下。因此,制定明确的指南对于正确诊断、进行适当治疗以及了解预防措施及其实施时机非常重要。在本文中,我们解释了在第11届国际抗磷脂抗体大会(2004年悉尼)上审议的最新诊断标准,对各种临床表现进行评论,特别关注皮肤病变,并回顾了目前针对血栓形成和产科病理的治疗及预防指南。

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