Paul Lynn K, Brown Warren S, Adolphs Ralph, Tyszka J Michael, Richards Linda J, Mukherjee Pratik, Sherr Elliott H
California Institute of Technology, MC 228-77 Pasadena, California 91125, USA.
Nat Rev Neurosci. 2007 Apr;8(4):287-99. doi: 10.1038/nrn2107.
Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.
胼胝体发育不全（AgCC）是指连接大脑半球的大量纤维束未能发育，其发病率为1/4000。遗传学、动物模型和详细的结构神经影像学研究正在为AgCC的发育和分子基础提供见解。使用神经心理学、脑电图和功能磁共振成像方法的研究正在检查由此导致的情绪和社会功能障碍，并已开始探索受损的高阶认知背后的功能性神经解剖学。对AgCC的研究可以为了解健康大脑的综合脑功能提供见解，并可能为理解某些精神疾病，如精神分裂症和自闭症提供一个模型。
