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1
Glutamate decarboxylase: an autoantigen in IDDM.谷氨酸脱羧酶：胰岛素依赖型糖尿病中的一种自身抗原。
Diabetes Care. 1992 Jan;15(1):132-5. doi: 10.2337/diacare.15.1.132.
2
Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies.重组谷氨酸脱羧酶（代表在人胰岛中表达的单一异构体）可检测出与胰岛素依赖型糖尿病相关的64,000-M(r)自身抗体。
Diabetes. 1992 Oct;41(10):1355-9. doi: 10.2337/diab.41.10.1355.
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Islet cell autoantigens in type 1 diabetes.1型糖尿病中的胰岛细胞自身抗原。
Eur J Clin Invest. 1996 Oct;26(10):827-38. doi: 10.1111/j.1365-2362.1996.tb02126.x.
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High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing IDDM is not a marker of symptomatic autonomic neuropathy.
Diabetes. 1994 Sep;43(9):1146-51. doi: 10.2337/diab.43.9.1146.
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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.胰岛素依赖型糖尿病中64K自身抗原被鉴定为γ-氨基丁酸合成酶谷氨酸脱羧酶。
Nature. 1990 Sep 13;347(6289):151-6. doi: 10.1038/347151a0.
6
Sensitive monoclonal antibody-based sandwich ELISA for determination of the diabetes-associated autoantigen glutamic acid decarboxylase GAD65.基于敏感单克隆抗体的夹心酶联免疫吸附测定法用于测定糖尿病相关自身抗原谷氨酸脱羧酶GAD65。
J Immunoassay. 1997 Nov;18(4):289-307. doi: 10.1080/01971529708005823.
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Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase.糖尿病中的胰岛细胞胞浆抗体以针对胰岛细胞抗原512和谷氨酸脱羧酶的抗体为代表。
Diabetes. 1995 Nov;44(11):1290-5. doi: 10.2337/diab.44.11.1290.
8
Prevalence of GAD65 and IA-2 autoantibodies in IDDM patients affected by diabetic nephropathy.糖尿病肾病患者中GAD65和IA-2自身抗体的患病率。
Diabetologia. 1997 Apr;40(4):485.
9
Persistent GAD 65 antibodies in longstanding IDDM are not associated with residual beta-cell function, neuropathy or HLA-DR status.长期胰岛素依赖型糖尿病患者体内持续存在的谷氨酸脱羧酶65抗体与残余β细胞功能、神经病变或HLA - DR状态无关。
Horm Metab Res. 1997 Oct;29(10):510-5. doi: 10.1055/s-2007-979091.
10
T-lymphocyte lines specific for glutamic acid decarboxylase (GAD) the 64K beta-cell antigen of IDDM.
Diabetes. 1992 Jan;41(1):118-21. doi: 10.2337/diab.41.1.118.

引用本文的文献

1
Characteristics and Prevalence of Latent Autoimmune Diabetes in Adults (LADA).成人隐匿性自身免疫性糖尿病（LADA）的特征与患病率
ISRN Pharmacol. 2012;2012:580202. doi: 10.5402/2012/580202. Epub 2012 Apr 8.
2
Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune disorders.不同自身免疫性疾病自身抗体对谷氨酸脱羧酶（GAD）表位识别的比较分析。
Clin Exp Immunol. 1999 Dec;118(3):349-56. doi: 10.1046/j.1365-2249.1999.01030.x.
3
Relationships among 64k autoantibodies, pancreatic beta-cell function, HLA-DR antigens and HLA-DQ genes in patients with insulin-dependent diabetes mellitus in Korea.韩国胰岛素依赖型糖尿病患者中64k自身抗体、胰岛β细胞功能、HLA - DR抗原与HLA - DQ基因之间的关系。
Korean J Intern Med. 1995 Jan;10(1):1-9. doi: 10.3904/kjim.1995.10.1.1.
4
Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with type 1 (insulin-dependent) diabetes mellitus.在澳大利亚人和患有1型（胰岛素依赖型）糖尿病的亚洲人中，谷氨酸脱羧酶抗体与HLA - DR基因型相关。
Diabetologia. 1992 Oct;35(10):996-1001. doi: 10.1007/BF00401432.

本文引用的文献

1
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins.新诊断糖尿病儿童中的自身抗体可使人类胰岛细胞蛋白发生免疫沉淀。
Nature. 1982 Jul 8;298(5870):167-9. doi: 10.1038/298167a0.
2
Insulin antibodies in insulin-dependent diabetics before insulin treatment.胰岛素依赖型糖尿病患者在胰岛素治疗前的胰岛素抗体。
Science. 1983 Dec 23;222(4630):1337-9. doi: 10.1126/science.6362005.
3
Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus.单卵三胞胎和双胞胎中最初患1型糖尿病情况不一致者的胰岛细胞抗体和β细胞功能。
N Engl J Med. 1983 Feb 10;308(6):322-5. doi: 10.1056/NEJM198302103080607.
4
Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.针对一种64,000道尔顿人类胰岛细胞抗原的抗体在胰岛素依赖型糖尿病临床发病之前就已出现。
J Clin Invest. 1987 Mar;79(3):926-34. doi: 10.1172/JCI112903.
5
Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice.用非肥胖糖尿病（NOD）小鼠的脾细胞转移自身免疫性糖尿病
Diabetes. 1986 Aug;35(8):855-60. doi: 10.2337/diab.35.8.855.
6
Insulin autoantibodies in the pre-diabetic period: correlation with islet cell antibodies and development of diabetes.糖尿病前期的胰岛素自身抗体：与胰岛细胞抗体的相关性及糖尿病的发生
Diabetologia. 1986 May;29(5):339-42. doi: 10.1007/BF00452073.
7
Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid.克隆于λgt - 11的脑谷氨酸脱羧酶：融合蛋白产生γ-氨基丁酸。
Science. 1986 May 30;232(4754):1138-40. doi: 10.1126/science.3518061.
8
Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.自身免疫性糖尿病从糖尿病NOD小鼠向健康新生小鼠的同基因转移。L3T4 +和Lyt-2 + T细胞均需存在。
J Exp Med. 1987 Oct 1;166(4):823-32. doi: 10.1084/jem.166.4.823.
9
Banting lecture 1986. Does a common mechanism induce the diverse complications of diabetes?1986年班廷讲座。共同机制会引发糖尿病的多种并发症吗？
Diabetes. 1987 Mar;36(3):396-406. doi: 10.2337/diab.36.3.396.
10
Predicting insulin-dependent diabetes.
Lancet. 1988 Apr 16;1(8590):845-50. doi: 10.1016/s0140-6736(88)91601-7.

Glutamate decarboxylase: an autoantigen in IDDM.

作者信息

Clare-Salzler M J, Tobin A J, Kaufman D L

机构信息

Department of Medicine, University of California, Los Angeles.

出版信息

Diabetes Care. 1992 Jan;15(1):132-5. doi: 10.2337/diacare.15.1.132.

DOI:10.2337/diacare.15.1.132
PMID:1737532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8223701/
Abstract
摘要