Kulakovskaia E V, Kulakovskaia T V, Golubev V I, Shashkov A S, Grachev A A, Nifant'ev N E
Bioorg Khim. 2007 Jan-Feb;33(1):167-71.
Cellobiose lipids of yeast fungi Cryptococcus humicola and Pseudozyma fusiformata have similar fungicidal activities against different yeast, including pathogenic Cryptococcus and Candida species. Basidiomycetic yeast reveals maximum sensitivity to these preparations; e.g., cells of cryptococcus Filobasidiella neoformans almost completely die after 30-min incubation in a glycolipid solution at a concentration of 0.02 mg/ml. The same effect toward ascomycetous yeast, including pathogenic Candida species, is achieved only at five to eight times higher concentrations of glycolipids. The cellobiose lipid from P. fusiformata, which, unlike glycolipid from Cr. humicola, has hydroxycaproic acid residue as O-subtituent of cellobiose and additional 15-hydroxy group in aglycone, inhibits the growth of the studied mycelial fungi more efficiently than the cellobiose lipid from Cr. humicola.
酵母真菌腐皮隐球菌和梭形假丝酵母的纤维二糖脂对不同酵母具有相似的杀真菌活性，包括致病性隐球菌和念珠菌属。担子菌酵母对这些制剂表现出最大敏感性；例如，新型隐球菌细胞在浓度为0.02mg/ml的糖脂溶液中孵育30分钟后几乎完全死亡。对包括致病性念珠菌属在内的子囊菌酵母，只有在糖脂浓度高五到八倍时才会产生同样的效果。与腐皮隐球菌的糖脂不同，梭形假丝酵母的纤维二糖脂在纤维二糖的O-取代基上有羟基己酸残基，糖苷配基上还有额外的15-羟基，它比腐皮隐球菌的纤维二糖脂更有效地抑制所研究的丝状真菌的生长。
