宫颈癌的锁骨上淋巴结转移

Supraclavicular lymph node metastases in cervical cancer.

作者信息

Qiu J T, Ho K C, Lai C H, Yen T C, Huang Y T, Chao A, Chang T C

机构信息

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

出版信息

Eur J Gynaecol Oncol. 2007;28(1):33-8.

PMID:17375703

Abstract

PURPOSE OF INVESTIGATION

To evaluate the outcome and prognostic factors of patients with supraclavicular lymph node (SCLN) involvement at primary diagnosis.

METHODS

We reviewed the medical records of cervical cancer patients primarily treated at Chang Gung Memorial Hospital between 1987 and 2005. Thirty-three patients with histologically confirmed SCLN metastasis at primary diagnosis were eligible for analysis. Clinical and pathological features were analyzed for association with outcome.

RESULTS

The 3- and 5-year survival rates of patients with SCLN metastasis were 16.5% and 16.5%, respectively. Multivariate analysis showed the serum level of squamous cell carcinoma antigen (SCC-Ag) < 15 ng/ml at initial diagnosis (p = 0.021) and staging/restaging including [18F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) (p = 0.006) to be associated with a better prognosis.

CONCLUSION

Primary SCLN metastasis in cervical cancer is not incurable. The benefit from PET findings might help in selecting appropriate patients for curative primary and/or salvage treatment.

摘要

研究目的

评估初诊时伴有锁骨上淋巴结（SCLN）转移的患者的治疗结果及预后因素。

方法

我们回顾了1987年至2005年在长庚纪念医院接受初次治疗的宫颈癌患者的病历。33例初诊时经组织学证实有SCLN转移的患者符合分析条件。分析临床和病理特征与治疗结果的相关性。

结果

SCLN转移患者的3年和5年生存率分别为16.5%和16.5%。多因素分析显示，初诊时鳞状细胞癌抗原（SCC-Ag）血清水平<15 ng/ml（p = 0.021）以及包括[18F]氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）在内的分期/再分期（p = 0.006）与较好的预后相关。