Kumar Vijay
IMMLO Diagnostics Inc., USA.
MLO Med Lab Obs. 2007 Feb;39(2):28, 30-1.
Pernicious anemia is severe anemia most often affecting older adults, caused by failure of the stomach to absorb vitamin B12 and characterized by abnormally large red blood cells, gastrointestinal disturbances, and lesions of the spinal cord. Pernicious anemia is caused by a lack of intrinsic factor and could be an autoimmune disorder. The identification of various autoantibodies helps in the confirmation of the diagnosis and hence towards the patient management. In such patients, oral supplements or intramuscular injections of vitamin B12 are indicated.
恶性贫血是一种最常影响老年人的严重贫血症，由胃无法吸收维生素B12引起，其特征是红细胞异常增大、胃肠道紊乱以及脊髓病变。恶性贫血是由于缺乏内因子所致，可能是一种自身免疫性疾病。各种自身抗体的鉴定有助于确诊，从而有助于患者的管理。对于此类患者，建议口服补充剂或注射维生素B12。
