D'Alessio D J, Peterson J A, Dick C R, Dick E C
J Infect Dis. 1976 Jan;133(1):28-36. doi: 10.1093/infdis/133.1.28.
Communicability of rhinovirus type 16 or type 55 was studied in 24 childless couples; on partner (the donor) was infected with laboratory-grown virus. Initially, both partners lacked antibody to the challenge agent. Rates of transmission between partners were 41% and 33% for type 16 and type 55, respectively. These rates are similar to those determined in epidemiologic studies of natural rhinovirus infection. Although the mucosa of the anterior nares was shown to be highly susceptible to infection (less than one 50% tissue culture infective dose [TCID50]), transmission rarely occurred unless (1) at least 1,000 TCID50 of virus was recovered from the donor's nasal washing, (2) the donor had virus on his hands and anterior nares, (3) he was at least moderately symptomatic, and (4) he spent many hours with his spouse. Since person-to-person transfer of rhinovirus was so dependent upon time spent together and shedding of large amounts of virus by the donor, it seems possible that the chain of infection could be interrupted by environmental manipulation.
在24对无子女夫妇中研究了16型或55型鼻病毒的传染性；一方伴侣（供体）感染了实验室培养的病毒。最初，双方伴侣均缺乏针对攻击病原体的抗体。16型和55型鼻病毒在伴侣之间的传播率分别为41%和33%。这些传播率与自然鼻病毒感染的流行病学研究中所确定的传播率相似。尽管已表明鼻前庭黏膜对感染高度敏感（低于一个50%组织培养感染剂量[TCID50]），但除非满足以下条件，传播很少发生：（1）从供体的鼻腔冲洗液中回收至少1000 TCID50的病毒；（2）供体的手部和鼻前庭有病毒；（3）他至少有中度症状；（4）他与配偶相处数小时。由于鼻病毒在人与人之间的传播如此依赖于在一起的时间以及供体大量排出病毒，因此似乎有可能通过环境控制来中断感染链。
