Juuti Anne, Lundin Johan, Nordling Stig, Louhimo Johanna, Haglund Caj
Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.
Oncology. 2006;71(1-2):61-8. doi: 10.1159/000100988. Epub 2007 Mar 21.
Matrix metalloproteinases (MMPs) degrade extracellular matrix and are involved in tumor invasion and metastasis in various cancers. In pancreatic cancer, MMP-2 expression is upregulated and correlates with tumor recurrence. The aim of this study was to evaluate the prognostic significance of MMP-2 in pancreatic ductal adenocarcinoma.
MMP-2 expression was assessed by immunohistochemistry in 127 patients operated on at Helsinki University Hospital from 1974 to 1998, with expression interpreted separately in epithelial and stromal samples.
Epithelial MMP-2 expression was strong in 5%, moderate in 20%, weak in 25% and negative in 50% of the tumors, with high epithelial MMP-2 expression significantly associated in univariate survival analysis with advanced stage, poor grade and poor survival. Stromal MMP-2 expression was strong in 0%, moderate in 14%, weak in 70% and negative in 16% of the cases, and did not significantly correlate with patient survival.
Epithelial MMP-2 correlates with advanced tumor stage and grade, but is not an independent predictor of survival.
基质金属蛋白酶（MMPs）可降解细胞外基质，并参与多种癌症的肿瘤侵袭和转移。在胰腺癌中，MMP-2表达上调且与肿瘤复发相关。本研究旨在评估MMP-2在胰腺导管腺癌中的预后意义。
采用免疫组织化学法对1974年至1998年在赫尔辛基大学医院接受手术的127例患者的MMP-2表达进行评估，并分别在上皮和基质样本中解读其表达情况。
在肿瘤中，上皮MMP-2表达强的占5%，中等强度的占20%，弱表达的占25%，阴性表达的占50%，单因素生存分析显示上皮MMP-2高表达与晚期、低分化及较差的生存率显著相关。基质MMP-2表达强的病例占0%，中等强度的占14%，弱表达的占70%，阴性表达的占16%，且与患者生存率无显著相关性。
上皮MMP-2与肿瘤晚期及低分化相关，但并非生存的独立预测因素。
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