丘脑切开术、丘脑底核脑深部电刺激术和苍白球内侧核脑深部电刺激术治疗全身性肌张力障碍：一例报告

Thalamotomy, DBS-Vim, and DBS-GPi for generalized dystonia: a case report.

作者信息

Schadt Courtney R, Charles P David, Davis Thomas L, Konrad Peter E

机构信息

Vanderbilt University School of Medicine, Nashville, TN 37212-3375, USA.

出版信息

Tenn Med. 2007 Feb;100(2):38-9.

PMID:17378506

Abstract

Generalized dystonia is a disabling disorder that can severely affect quality of life. Pharmacological treatment is unsatisfactory, and surgical therapy has been the focus for symptom improvement. We present the first case report of a patient with disabling generalized dystonia treated with a thalamotomy and deep brain stimulation of the thalamus and globus pallidus (DBS-Vim, DBS-GPi). His tremor and dystonic symptoms have dramatically improved through combining these surgical interventions.

摘要

全身性肌张力障碍是一种致残性疾病，会严重影响生活质量。药物治疗效果不佳，手术治疗一直是改善症状的重点。我们报告首例采用丘脑切开术以及丘脑和苍白球深部脑刺激术（Vim核深部脑刺激术、苍白球内侧部深部脑刺激术）治疗致残性全身性肌张力障碍患者的病例。通过联合这些手术干预，患者的震颤和肌张力障碍症状得到显著改善。