苍白球深部脑刺激治疗肌张力障碍
Globus pallidus deep brain stimulation in dystonia.
作者信息
Diamond Alan, Shahed Joohi, Azher Shaheda, Dat-Vuong Kevin, Jankovic Joseph
机构信息
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Mov Disord. 2006 May;21(5):692-5. doi: 10.1002/mds.20767.
Globus pallidus deep brain stimulation (GPi-DBS) is a useful alternative in the treatment of dystonia. Patients selected for GPi-DBS were prospectively rated with the Unified Dystonia Rating Scale (UDRS). Also, "blinded" videotape assessments were performed. Eleven patients were identified. Compared with pre-DBS scores, there were improvements in mean total UDRS score (15.3%) and in the following subscores: neck (18.18%), trunk (32.9%), arm (17.9%), and leg (19.9%). One patient developed a skin infection and erosion requiring surgical debridement. GPi-DBS is a safe and effective treatment for generalized dystonia in patients who remained impaired, despite optimal medical therapy.
苍白球内侧部脑深部电刺激术（GPi-DBS）是治疗肌张力障碍的一种有效替代方法。入选GPi-DBS治疗的患者采用统一肌张力障碍评定量表（UDRS）进行前瞻性评分。此外，还进行了“盲法”录像评估。共确定了11例患者。与脑深部电刺激术前评分相比，UDRS总均分（提高了15.3%）以及以下各分项评分均有所改善：颈部（提高了18.18%）、躯干（提高了32.9%）、手臂（提高了17.9%）和腿部（提高了19.9%）。1例患者发生皮肤感染和糜烂，需要手术清创。对于尽管接受了最佳药物治疗仍有功能障碍的全身性肌张力障碍患者，GPi-DBS是一种安全有效的治疗方法。
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