Jovanovski Diana, Zakzanis Konstantine K, Young Donald A, Campbell Zachariah
Department of Life Sciences (Psychology), University of Toronto at Scarborough, 1265 Military Trail, Toronto, ON, Canada M1C 1A4.
Psychiatry Res. 2007 May 30;151(1-2):47-54. doi: 10.1016/j.psychres.2006.09.012. Epub 2007 Mar 26.
Past research has found that deficits in insight into illness are related to executive deficits in schizophrenia. This study further explores this relationship with the utilization of an ecologically-valid battery of executive tests. The study included 21 patients with schizophrenia who were administered the Behavioural Assessment of the Dysexecutive Syndrome (BADS) and the first three items of the Scale to Assess Unawareness of Mental Disorder. Patients were found to be impaired on the BADS and most had insight into their illness. Lack of illness awareness was not significantly correlated with all of the BADS subtests with the exception of Rule Shift Cards, a measure of cognitive flexibility. The relationship between some measures of unawareness and Rule Shift Cards was still significant or approaching significance when the effects of IQ were partialled out. These findings add to previous research by demonstrating that cognitive flexibility, specifically involving the ability to shift set, is associated with awareness of illness in schizophrenia. On the other hand, it is proposed that most of the other BADS subtests are more complex and multifactorial, thereby making it difficult to find any associations that may exist between a specific subdimension of executive function and insight into illness.
过去的研究发现,对疾病的洞察力缺陷与精神分裂症的执行功能缺陷有关。本研究通过使用一系列具有生态效度的执行功能测试,进一步探究了这种关系。该研究纳入了21名精神分裂症患者,对他们进行了执行功能障碍综合征行为评估(BADS)以及精神障碍自知力评估量表的前三项测试。结果发现,患者在BADS测试中表现受损,且大多数患者对自己的病情有洞察力。除了作为认知灵活性指标的规则转换卡片测试外,缺乏疾病自知力与BADS的所有子测试均无显著相关性。在排除智商的影响后,一些自知力指标与规则转换卡片测试之间的关系仍然显著或接近显著。这些发现进一步证明,认知灵活性,特别是涉及转换定势的能力,与精神分裂症患者的疾病自知力相关,从而补充了先前的研究。另一方面,有人提出,BADS的大多数其他子测试更为复杂且具有多因素性,因此难以发现执行功能的特定子维度与疾病洞察力之间可能存在的任何关联。