Amaki Makoto, Kamide Kei, Takiuchi Shin, Niizuma Shinichiro, Horio Takeshi, Kawano Yuhei
Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan.
Int Heart J. 2007 Jan;48(1):123-7. doi: 10.1536/ihj.48.123.
A 69-year-old man had been suffering from recurrent syncope induced by laughter since the age of 58. His syncope was reproduced by head-up tilt testing with isoproterenol infusion and we concluded that his laughter-induced syncope was one type of neurally mediated syndrome (NMS). His daughter also had NMS and her syncope was treated with propranolol. Propranolol and midodrine hydrochloride, an alpha(1)-adrenergic stimulant, were effective at preventing his laughter-induced syncope. This is a case report of laughter-induced syncope with a familial predisposition successfully treated with the combination of the nonselective beta-blocker propranolol and the alpha(1)-stimulator midodrine.
一名69岁男性自58岁起就一直患有因大笑诱发的反复晕厥。通过静脉输注异丙肾上腺素进行头高位倾斜试验可再现其晕厥症状，我们由此得出结论，他的大笑诱发的晕厥属于神经介导性综合征（NMS）的一种类型。他的女儿也患有NMS，其晕厥通过普萘洛尔进行了治疗。普萘洛尔和α1肾上腺素能兴奋剂盐酸米多君可有效预防他的大笑诱发的晕厥。本文报告了一例具有家族易感性的大笑诱发的晕厥病例，通过联合使用非选择性β受体阻滞剂普萘洛尔和α1兴奋剂米多君成功治愈。
