一个使神经元细胞命运多样化的微小RNA控制的基因调控网络的架构。
Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates.
作者信息
Hobert O
机构信息
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA.
出版信息
Cold Spring Harb Symp Quant Biol. 2006;71:181-8. doi: 10.1101/sqb.2006.71.006.
Individual cell types are defined by the expression of specific gene batteries. Regulatory networks that control cell-type-specific gene expression programs in the nervous system are only beginning to be understood. This paper summarizes a complex gene regulatory network, composed of several transcription factors and microRNAs (miRNAs), that controls neuronal subclass specification in the nervous system of the nematode Caenorhabditis elegans.
个体细胞类型由特定基因组合的表达所定义。控制神经系统中细胞类型特异性基因表达程序的调控网络才刚刚开始被理解。本文总结了一个复杂的基因调控网络，它由几种转录因子和微小RNA（miRNA）组成，控制着线虫秀丽隐杆线虫神经系统中神经元亚类的特化。
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