Rose L S, Kemphues K J
Section of Molecular and Cellular Biology, University of California, Davis 95616, USA.
Annu Rev Genet. 1998;32:521-45. doi: 10.1146/annurev.genet.32.1.521.
Studies of about 20 maternally expressed genes are providing an understanding of mechanisms of patterning and cell-fate determination in the early Caenorhabditis elegans embryo. The analyses have revealed that fates of the early blastomeres are specified by a combination of intrinsically asymmetric cell divisions and two types of cell-cell interactions: inductions and polarizing interactions. In this review we summarize the current level of understanding of the molecular mechanisms underlying these processes in the specification of cell fates in the pregastrulation embryo.
对约20个母源表达基因的研究，正在让人们了解秀丽隐杆线虫早期胚胎中的模式形成和细胞命运决定机制。分析表明，早期卵裂球的命运由内在不对称细胞分裂以及两种细胞间相互作用共同决定：诱导作用和极化相互作用。在这篇综述中，我们总结了目前对于原肠胚形成前胚胎细胞命运特化过程中这些机制的分子机制的理解水平。
