使用戈林公式和基于心血管磁共振的混合方法验证峰均值压力降低率作为评估主动脉瓣狭窄的新方法。

Validation of the peak to mean pressure decrease ratio as a new method of assessing aortic stenosis using the Gorlin formula and the cardiovascular magnetic resonance-based hybrid method.

作者信息

Haghi Dariusch, Kaden Jens J, Suselbeck Tim, Fluechter Stephan, Breithardt Ole A, Poerner Tudor, Kalmar Gabor, Borggrefe Martin, Papavassiliu Theano

机构信息

Medical Department, University Hospital Mannheim, Mannheim, Germany.

出版信息

Echocardiography. 2007 Apr;24(4):335-9. doi: 10.1111/j.1540-8175.2007.00416.x.

DOI:10.1111/j.1540-8175.2007.00416.x

PMID:17381640

Abstract

BACKGROUND

We sought to validate the recently introduced peak to mean pressure decrease ratio (PMPDR), using the Gorlin formula and a hybrid method which combines cardiovascular magnetic resonance (CMR)-derived stroke volume with transaortic Doppler measurements to calculate aortic valve area (AVA).

METHODS

Data analysis in 32 patients with severe (AVA <or= 0.75 cm(2)) or moderate aortic stenosis who had prospectively been entered into our aortic stenosis database.

RESULTS

Gorlin-derived AVA was 0.61 +/- 0.10 cm(2) in severe and 0.92 +/- 0.14 cm(2) in moderate aortic stenosis (P < 0.01). Corresponding values for PMPRD were 1.61 +/- 0.10 and 1.73 +/- 0.18, respectively (P < 0.05). Sensitivity, specificity, positive and negative predictive values for PMPDR <1.5 to predict severe aortic stenosis were 0.12, 0.92, 0.67, and 0.44 as assessed by the Gorlin formula.

CONCLUSIONS

Using the Gorlin formula as the reference standard, our study confirms results of a previously reported study on the performance of PMPDR for assessment of aortic stenosis.

摘要

背景

我们试图验证最近引入的峰压与平均压降低率（PMPDR），使用戈林公式以及一种将心血管磁共振（CMR）得出的每搏输出量与经主动脉多普勒测量相结合以计算主动脉瓣面积（AVA）的混合方法。

方法

对32例重度（AVA≤0.75 cm²）或中度主动脉瓣狭窄患者的数据分析，这些患者已前瞻性地纳入我们的主动脉瓣狭窄数据库。

结果

重度主动脉瓣狭窄患者经戈林公式得出的AVA为0.61±0.10 cm²，中度患者为0.92±0.14 cm²（P<0.01）。PMPRD的相应值分别为1.61±0.10和1.73±0.18（P<0.05）。经戈林公式评估，PMPDR<1.5预测重度主动脉瓣狭窄的敏感性、特异性、阳性预测值和阴性预测值分别为0.12、0.92、0.67和0.44。