Lories Rik J U, Luyten Frank P
Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Belgium.
Arthritis Res Ther. 2007;9(2):207. doi: 10.1186/ar2135.
Joint destruction and tissue responses determine the outcome of chronic arthritis. Joint inflammation and damage are often the dominant clinical presentation. However, in some arthritic diseases, in particular the spondyloarthritides, joint remodeling is a prominent feature, with new cartilage and bone formation leading to ankylosis and contributing to loss of function. A role for bone morphogenetic proteins in joint remodeling has been demonstrated in the formation of both enthesophytes and osteophytes. Data from genetic models support a role for bone morphogenetic protein signaling in cartilage homeostasis. Finally, this signaling pathway is likely to play a steering role in the synovium.
关节破坏和组织反应决定了慢性关节炎的结局。关节炎症和损伤通常是主要的临床表现。然而，在某些关节炎疾病中，尤其是脊柱关节炎，关节重塑是一个突出特征，新的软骨和骨形成导致关节强直并导致功能丧失。骨形态发生蛋白在关节重塑中的作用已在附着点骨赘和骨赘的形成中得到证实。遗传模型的数据支持骨形态发生蛋白信号在软骨稳态中的作用。最后，该信号通路可能在滑膜中起导向作用。
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