神经内分泌肿瘤的生物化学

Biochemistry of neuroendocrine tumours.

作者信息

de Herder Wouter W

机构信息

Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, 3015 CE Rotterdam, The Netherlands.

出版信息

Best Pract Res Clin Endocrinol Metab. 2007 Mar;21(1):33-41. doi: 10.1016/j.beem.2006.12.002.

DOI:10.1016/j.beem.2006.12.002

PMID:17382264

Abstract

Several circulating or urinary tumour markers can be used for the diagnosis and follow-up of functioning and clinically non-functioning neuroendocrine tumours of the pancreatic islet cells and intestinal tract. Among the specific tumour markers are serotonin and its metabolites--e.g. 5-hydroxyindoleacetic acid (5-HIAA)--in carcinoid tumours and the carcinoid syndrome, insulin and its precursors or breakdown products in insulinoma, and gastrin in gastrinoma. Plasma vasointestinal polypeptide (VIP) determinations have been used in the diagnosis of VIPoma, plasma glucagon for glucagonoma, and serum somatostatin for somatostatinoma. Among the tumour-non-specific markers are: chromogranins, neuron-specific enolase (NSE), alpha-subunits of the glycoprotein hormones, catecholamines, pancreatic polypeptide (PP), ghrelin and adrenomedullin.

摘要

几种循环或尿液肿瘤标志物可用于诊断和随访胰岛细胞及肠道的功能性和临床无功能性神经内分泌肿瘤。特异性肿瘤标志物包括类癌肿瘤和类癌综合征中的血清素及其代谢产物，如5-羟吲哚乙酸（5-HIAA）；胰岛素瘤中的胰岛素及其前体或分解产物；胃泌素瘤中的胃泌素。血浆血管活性肠肽（VIP）测定已用于诊断VIP瘤，血浆胰高血糖素用于诊断胰高血糖素瘤，血清生长抑素用于诊断生长抑素瘤。肿瘤非特异性标志物包括：嗜铬粒蛋白、神经元特异性烯醇化酶（NSE）、糖蛋白激素的α亚基、儿茶酚胺、胰多肽（PP）、胃饥饿素和肾上腺髓质素。