Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)).
作者信息
Vasu Vihas T, Hobson Brad, Gohil Kishorchandra, Cross Carroll E
机构信息
Department of Internal Medicine, Centre for Comparative Respiratory Biology and Medicine, Genome and Biomedical Sciences Facility, Lab 6404A, 451 East Health Sciences Drive, UC Davis, Davis, CA 95616, USA.
出版信息
FEBS Lett. 2007 Apr 17;581(8):1572-8. doi: 10.1016/j.febslet.2007.03.017. Epub 2007 Mar 15.
Abstract
Alpha-tocopherol transfer protein (ATTP) null mice (ATTP(-/-)) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP(-/-) are <10% of those in ATTP(+/+) mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP(-/-) mice and compared with their ATTP(+/+) littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of approximately 13000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP(-/-) as compared to ATTP(+/+) mice. The present data identifies novel classes of AT sensitive genes in heart tissue.
摘要
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